Reproduction and Contraception


Safe and effective treatment option for unwanted mating and pregnancy in dogs

  • Dog
  • Injectable

Alizin® is the most safe and effective treatment option for unwanted mating and pregnancy in dogs, and it can be used up to 45 days after mating.

Alizin® contains aglepristone which is a synthetic progesterone antagonist, meaning that it attaches to, and binds tightly to progesterone receptors on the uterus without activating the receptors. This blocks the effects of progesterone. Progesterone is required to allow embryos to implant into the wall of the uterus and is required to maintain pregnancy.

When progesterone is blocked by Alizin® fertilised ova will not be able to implant and so pregnancy is not established. Alizin® will also stop the maintenance of the appropriate environment in the uterus and pregnancy will be lost.

Dogs running in grassThe treatment is two injections given under the skin 24 hours apart. The treatment is very safe with an excellent safety profile. When given before 21 days after mating, the treatment is 99% effective. When given between 21 and 45 days after mating the treatment is about 95% effective. Treating after 45 days post-mating is not recommended.

When your dog has mated or become pregnant and it would be unwanted, unwise or dangerous to let the pregnancy continue, it can be an emotional and difficult time. The decision to terminate a pregnancy is not taken lightly. Talk to your vet to discuss if using Alizin® is the right treatment for your dog.


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Alizin® is a Restricted Veterinary Medicine. Available only under Veterinary Authorisation. Registered pursuant to the ACVM Act 1997, No. A7957.

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Frequently Asked Questions
  • I am a veterinarian however I do not live in New Zealand. How can I purchase Alizin?

    If you are a registered veterinarian you may be able to import Alizin from Australia. If you are based in the USA you will need a special import license from the FDA. 

    Click here to contact the Australian Provet Export team for more information.

  • I am a dog owner interested in purchasing Alizin however I do not live in New Zealand. What should I do?

    Alizin is a product that must be prescribed by your veterinarian. It is not a product licensed for sale in the USA.

    Please contact your local veterinarian to seek more information.